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[snip] i checked the installation and found that this key doesn't exist. > PythonWin32Exists := RegKeyExists(HKLM, 'Software\Python\Pythonwin'); [snip] I poked around a little bit in the cvs server of the win32 extensions project at sourceforge and couldn't find any trace of this key. It seems that the installation only writes below "Software\Python\PythonCore". Is it possible that this key has been generated by the WISE installer, which was formerly used? For about 7 month the project uses distutils and maybe this key has lost while switching the installation. Olaf